Combination Hormonal Therapy (CHT): Also referred to as Combined Hormonal Blockage (CHB), or Combined Androgen Deprivation Therapy (ADT).  The preferred term is ADT, often designed with a number referring to the number of agents used (i.e, mono-therapy ADT, ADT2, ADT3). This combined therapy can utilize a number of mechanisms, including surgical or medical ADT, anti-androgens, 5-alpha reductase inhibitors, estrogenic compounds, agents that block adrenal androgen production, and agents that decrease the receptivity of the androgen receptor.